Thyroid Hormone Receptor Interactor 3 (TRIP3)

The thyroid hormone receptors (TRs) are hormone-dependent transcription factors that regulate expression of a variety of specific target genes.

TRIP3 interacted with rat Thrb only in the presence of thyroid hormone. It also showed a ligand-dependent interaction with RXR-alpha (RXRA), but did not interact with the glucocorticoid receptor (NR3C1) under any condition. A region of TRIP3 that includes a number of negatively charged residues shows similarity to several short regions of the Drosophila CUT protein, a homeodomain-containing transcription factor. Northern blot analysis detected a 1.1-kb TRIP3 transcript in all tissues examined.