Zinc Finger MIZ Domain Containing Protein 1 (ZMIZ1)

ZMIZ1 encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.

The deduced 1,067-amino acid protein has a calculated molecular mass of 123 kD. RAI17 contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. In vitro transcription and translation resulted in a protein with an apparent molecular mass of 130 kD.