Zinc Finger Protein 143 (ZNF143)

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. One abundant class of such transcriptional regulators resembles the Drosophila Kruppel segmentation gene product due to the presence of repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links. Like Staf, both ZNF76 and ZNF143 contain 7 zinc fingers and an activation domain with the mRNA and snRNA activation regions. Both proteins bound Staf-responsive elements in vitro. Chimeric ZNF76 and ZNF143 proteins activated a pol II mRNA promoter and snRNA pol II and pol III promoters in Xenopus oocytes.