Zinc Finger Protein 181 (ZNF181)

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions, such as stimulation of transcription, transcriptional repression, binding to single-stranded DNA, binding to RNA, or bifunctional DNA- and RNA-binding activities. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc.

By screening a human fetal heart cDNA library with a degenerate oligonucleotide based on the consensus sequence of the C2H2 zinc finger domain, Wang et al. (1996) cloned 2 novel zinc finger cDNAs, designated ZNF180 and ZNF181.By FISH, Wang et al. (1996) mapped the ZNF180 and ZNF181 genes within a cluster of zinc finger genes on chromosome 19q13.2.