Zinc Finger Protein 184 (ZNF184)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA.

By exon trapping using YAC contigs spanning the 6p21.3 region, which contains a cluster of zinc finger protein genes, Goldwurm et al. (1997) isolated a partial cDNA, designated ZNF184, from a placental library. Sequence analysis indicated that ZNF184 is a classic Kruppel zinc finger gene with a conserved C2H2 domain at the C terminus and Kruppel-associated boxes (KRAB) A and B at the N terminus. Northern blot analysis revealed expression of ZNF184 as a 3.2-kb transcript in all tissues analyzed, with predominant expression in testis.