Zinc Finger Protein 189 (ZNF189)

The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.The exons encode a predicted KRAB A domain at the N terminus, a spacer region, and 16 zinc finger motifs at the C terminus; all identified splice variants encode the spacer region and zinc finger domain. Northern blot analysis demonstrated that ZNF189 was expressed in all tissues and cell types investigated, with the different splice variants showing tissue- or cell type-restricted expression patterns. This expression analysis also detected 2 additional unidentified splice variants. ZNF189 gene is well-conserved in several mammalian species.