Zinc Finger Protein 23 (ZNF23)

Cannizzaro et al. (1993) mapped a member of the KOX gene family, ZNF23 (KOX16), to 16q22 by in situ hybridization. The map location is near the site of 2 fragile sites, FRA16B and FRA16C. The 16q22 region has been involved, furthermore, in chromosomal alterations characteristic of acute myeloid leukemia. The ZNF19 gene maps to the same region. Analogous genes in the mouse map to chromosome 8 in a region of syntenic homology. By pulsed field gel electrophoresis experiments, Rousseau-Merck et al. (1993) showed that the ZNF19 and ZNF23 genes lie within a 200-300 kb DNA fragment. A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA.