Zinc Finger Protein 266 (ZNF266)

HZF1

Zinc Finger Protein 266 (ZNF266)
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. By screening a human monoblast cell line (U-937) cDNA library with a degenerate oligonucleotide based on a conserved region of Kruppel-related zinc finger proteins that encompasses the H/C link, Abrink et al. (1995) isolated cDNAs encoding 42 distinct Kruppel-related zinc finger proteins, including ZNF266, which they called HZF1. The partial ZNF266 cDNA, which lacks 5-prime coding sequence, encodes 7 C-terminal zinc finger domains. Northern blot analysis detected a major 4.5-kb ZNF266 transcript in HeLa cells, U-937 cells, and PMA-induced U-937 cells, with higher expression in the monocyte/macrophage lineages.

Organism species: Homo sapiens (Human)