Zinc Finger Protein 32 (ZNF32)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.

Cannizzaro et al. (1993) mapped the ZNF32 (KOX30) gene by in situ hybridization to chromosome 10q23-q24. The site is near that which, under certain in vitro conditions, demonstrates the development of fragile sites: FRA10D, FRA10A, FRA10B, and FRA10E. Furthermore, deletions in the 10q23-q24 region have been observed in association with malignant lymphoma and carcinoma of the prostate.