Zinc Finger Protein 35 (ZNF35)

Zinc fingers are protein DNA-binding domains that consist of tandemly repeated units of 28 to 30 amino acids containing 2 cysteine and 2 histidine residues at invariant positions. The finger motif has been identified in several eukaryotic transcriptional regulatory proteins and members of the finger-gene family are implicated in both proliferation and differentiation of normal cells.

ZNF35 gene spans about 13 kb and is interrupted by 3 introns. All 11 zinc finger DNA-binding domains are contiguously encoded within the last 3-prime exon.HF.10, is expressed at low levels in a variety of human tissues and is downregulated during the in vitro terminal differentiation of human leukemic myeloid cell lines.