Zinc Finger Protein 382 (ZNF382)

ZNF382 contains N-terminal KRAB A and KRAB B domains, followed by a vestigial zinc finger, a nuclear localization signal, and 9 tandemly repeated Kruppel-type C2H2-zinc finger domains at its C terminus. ZNF382 shares 91% and 83% amino acid identity with rat Ks1 in the KRAB and zinc finger domains, respectively. Northern blot analysis detected a 2.9-kb transcript abundantly expressed in heart. Weaker expression was detected in skeletal muscle, but no expression was detected in 6 other tissues examined. Expression of ZNF382 was more widespread in human fetal tissues. Whole 34- and 40-day embryos showed high ZNF382 expression. At later developmental stages, ZNF382 was detected predominantly in cerebellum, kidney, and cerebrum, and to a lesser extent in lung, heart, skeletal muscle, tongue, and adrenal gland.