Zinc Finger Protein 43 (ZNF43)

ZNF43 belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.

These cDNAs encode predicted 803- and 809-amino acid proteins containing N-terminal KRAB A and KRAB B boxes, 22 contiguous zinc finger domains of the C2H2 type, and a C-terminal region of 18 amino acids. Northern blot analysis showed that ZNF43 expression is low and limited to B- and T-cell lines.These proteins contain a conserved linker region, called the ZNF91-related spacer region, between their N-terminal KRAB domain and their first finger unit.