encodes a zinc-finger protein. Low-percent homology to certain collagens suggests that it may function as a transcription factor or extra-nuclear regulator factor for the synthesis or organization of collagen fibers. Mutations in this gene cause brittle cornea syndrome.
By sequencing clones with the potential to encode large proteins expressed in brain, Nagase et al. (2001) identified ZNF469, which they designated KIAA1858. The deduced protein contains 772 amino acids. RT-PCR ELISA detected moderate ZNF469 expression in most adult and fetal tissues and specific adult brain regions examined. Expression was lower only in adult pancreas.