Zinc Finger Protein 62 Homolog (ZFP62)

Zfp62 was not expressed in 2 mouse fibroblast cell lines, but was induced during their myogenic conversion by transfection with muscle regulatory genes. Expression was also upregulated following myogenic induction in a rhabdomyosarcoma cell line.The deduced 522-amino acid protein contains 17 tandem canonical C2H2 zinc finger domains, none of which are in the C terminus. Northern blot analysis detected Zfp62 expression in adult skeletal and cardiac muscle and in spleen, with weaker expression in kidney. In situ hybridization of postimplantation mouse embryos detected diffuse Zfp62 expression, at highest levels in neural tube, encephalic vesicles, somites, and limb buds. Later in fetal development, Zfp62 was expressed in many tissues of neuroectodermal and mesodermal origin.