Zinc Finger Protein 653 (ZNF653)

The deduced 615-amino acid protein has a calculated molecular mass of 67.234 kD, which was confirmed experimentally. ZNF653 contains 2 predicted nuclear localization signals and 5 classic C2H2 zinc fingers. It shares 90% sequence identity with the acid mouse homolog. Multiple human tissue expression array hybridization detected ZNF653 mRNA expression at high levels in testis, cerebellum, temporal lobe, and hippocampus, followed by relatively high expression in adrenal gland, moderate expression in spleen and uterus, and lower expression in thymus, pancreas, kidney, stomach, and rectum.ZNF653 repressed SF1-dependent transcription. ZNF653 may act as a more general repressor of transcription by competition with GRIP1 and other p160 coactivators for binding to SF1.