Zinc Finger Protein 746 (ZNF746)

ZNF746 Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 4 C2H2-type zinc fingers.Contains 1 KRAB domain. May act as a downstream effector of PARK2 and contribute to neurodegeneration in Parkinson disease cases caused by defects in PARK2: its accumulation due to the absence of PARK2, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra.

Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. Ubiquitinated by PARK2. 'Lys-48'-linked polyubiquitination by PARK2 leads to degradation by the proteasome and may play a key role in regulation of neuron death.