Zinc Fingers And Homeoboxes Protein 2 (ZHX2)

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. ZHX2 encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.

The deduced 837-amino acid protein shares about 40% identity with mouse Zhx1. RT-PCR ELISA detected expression in all tissues examined, with highest levels in ovary, followed by lung, heart, kidney, brain, and liver. Intermediate expression was detected in pancreas, spleen, testis, and skeletal muscle.