cAMP Responsive Element Binding Protein 3 Like Protein 3 (CREB3L3)

CREB3L3 is a liver-specific transcription factor and member of the CREB/ATF transcription factor family. The deduced 463-amino acid protein contains a C-terminal b-ZIP domain, a putative transmembrane domain, a leucine zipper domain, and a KDEL-like sequence. Northern blot analysis of human tissues detected a 2.5-kb transcript exclusively in liver. Fluorescence microscopy localized CREB3L3 to the endoplasmic reticulum (ER).

CREB3L3 activated transcription of luciferase and box-B reporters via its N-terminal 141 amino acids. Gel mobility shift assay demonstrated that CREB3L3 specifically bound CRE and the box-B element.CREBH plays a critical role in activation of the acute inflammatory response.