Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Homo sapiens (Human) Recombinant protein

FRCP2; Irisin; Fibronectin type III repeat-containing protein 2

  • Product No.RPN576Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationMembrane
  • Predicted Molecular Mass16.6kDa
  • Accurate Molecular Mass18kDa(Analysis of differences refer to the manual)
  • Residues & TagsLeu2~Ile137 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 90%
  • Isoelectric Point6.2
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 1g Ensure in stock; if not, free redo!
  • FOB US$ 175.00 FREE TRIAL US$ 438.00 FREE TRIAL US$ 876.00 FREE TRIAL US$ 2,628.00 FREE TRIAL US$ 65,700.00 FREE TRIAL
  • Quantity
  • Add to Cart Distributors
  • Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Packages (Simulation)
  • Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Packages (Simulation)
  • RPN576Hu01.jpg SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Reference

  • Diabetes Research and Clinical PracticeSerum irisin levels in new-onset type 2 diabetesPubMed: 23369227
  • Journal of diabetes and its complicationsLower circulating irisin is associated with type 2 diabetes mellitusPubmed: 23619195
  • Horm Metab Res.Inconsistency in circulating irisin levels: what is really happeningPubmed:24459033
  • Int J Obes (Lond).Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in micePubmed:25199621
  • Molecular and Cellular EndocrinologyFenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese micePubmed:25576856
  • journal of diabetesLower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysisPubMed: 25494632
  • The Journal of Maternal-Fetal & Neonatal MedicineMaternal circulating levels of irisin in intrahepatic cholestasis of pregnancyPubMed: 26689349
  • Hormone and Metabolic ResearchLower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic Review and Meta-AnalysisPubmed:27300472
  • Nature Reviews EndocrinologyPhysiology and role of irisin in glucose homeostasis.pubmed:28211512
  • Journal of Molecular and Cellular CardiologyIrisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese micepubmed:27638193

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