Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Homo sapiens (Human) Recombinant protein

FRCP2; Irisin; Fibronectin type III repeat-containing protein 2

  • Product No.RPN576Hu01
  • Organism SpeciesHomo sapiens (Human)
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular Locationn/a
  • Predicted Molecular Mass16.9kDa
  • Accurate Molecular Massn/a(Analysis of differences refer to the manual)
  • Residues & TagsLeu2~Ile137 (Accession # Q8NAU1) with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Pointn/a
  • ApplicationsSDS-PAGE; WB; ELISA; IP.
  • DownloadInstruction Manual
  • UOM 10ug50ug 250ug 1mg 1g
  • FOB US$ 175US$ 438 US$ 1095 US$ 2628 US$ 65700
  • Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Package and Components
  • Recombinant Fibronectin Type III Domain Containing Protein 5 (FNDC5) Package and Components
  • RPN576Hu01.jpg SDS-PAGE
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

SEQUENCE

USAGE

Reconstitute in PBS or others.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Reference

  • Diabetes Research and Clinical PracticeSerum irisin levels in new-onset type 2 diabetesPubMed: 23369227
  • Journal of diabetes and its complicationsLower circulating irisin is associated with type 2 diabetes mellitusPubmed: 23619195
  • Horm Metab Res.Inconsistency in circulating irisin levels: what is really happeningPubmed:24459033
  • Int J Obes (Lond).Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in micePubmed:25199621
  • Molecular and Cellular EndocrinologyFenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese micePubmed:25576856
  • The Journal of Maternal-Fetal & Neonatal MedicineMaternal circulating levels of irisin in intrahepatic cholestasis of pregnancyPubMed: 26689349