Arylsulfatase B (ARSB)

Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

The deduced 533-residue protein has 6 potential N-glycosylation sites. Comparison of the predicted amino acid sequences of arylsulfatases A (ARSA), B, and C (ARSC) demonstrated regions of identity, particularly in their N termini.