Cyclin Dependent Kinase 5 (CDK5)

PSSALRE; CDKN5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit;TPKII catalytic subunit
Cyclin Dependent Kinase 5 (CDK5)
Recently Cdk5 has emerged as an essential kinase in sensory pathways. Recent reports of Pareek et al. from NIH suggest its necessity in pain signaling. CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1 or CDK5R2. Unlike other cyclin dependent kinases, CDK5 does not also require phosphorylation on the T loop so that binding with the activator is sufficient to activate the kinase. Cdk5 is involved in the processes of neuronal maturation and migration, phosphorylating the key intracellular adaptor of the reelin signaling chain.Experiments performed on mice lacking p35, a necessary activator of cdk5 in early brain development, showed that the normal layering of neurons was reversed in the cortex.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
  • Protein RPA739Mu01Recombinant Cyclin Dependent Kinase 5 (CDK5)Customize
  • AntibodyPAA739Mu01Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)Customize
  • AntibodyMAA739Mu21Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)Customize
  • Assay KitSEA739MuELISA Kit for Cyclin Dependent Kinase 5 (CDK5)Customize
  • Assay KitSCA739MuCLIA Kit for Cyclin Dependent Kinase 5 (CDK5)Customize
Organism species: Rattus norvegicus (Rat)
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