Mitogen Activated Protein Kinase 8 (MAPK8)
JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; JUN N-Terminal Kinase; Stress-activated protein kinase 1c; c-Jun N-terminal kinase 1
Mitogen-activated protein kinase 8
is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)