Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A10
, permit cellular efflux of zinc.
By searching databases with ZNT sequences, Seve et al. (2004) identified SLC30A10, which they called ZNT10. The deduced protein has a calculated molecular mass of 52.7 kD. It has 6 transmembrane helices, a basic region between helices 4 and 5, and cytoplasmic N and C termini. EST database analysis showed evidence of SLC30A10 expression only in fetal brain and fetal liver.Seve et al. (2004) determined that the SLC30A10 gene contains 4 exons and spans 15 kb.