Cavia Model for Arrhythmia Cavia (Guinea pig ) Disease model

Cardiac Arrhythmia

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by aconitine
  • Model Animal StrainsGuinea pig, healthy, half male and half female, body weight 350g~700g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Periodn/a
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  • Cavia Model for Arrhythmia Packages (Simulation)
  • Cavia Model for Arrhythmia Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Use guinea pig with body weight of 250-350g, stun the animals and open the chest to remove the heart, place the heart in a 4°C pre-cooled oxygen-enriched perfusate, squeeze out the heart cavity blood. Line Langendorff reverse irrigation, The perfusate is K-H solution, heart resuscitation, stop irrigation when heart jump more than 15 mins. Left atrial intubation, cut a small hole in the main pulmonary artery opening to facilitate the infusion of perfusion, the left atrial cisternation, connect to the physiological recorder, the heart smooth beating 3hours. Injest the treated perfusate aconitine 25Ug/ml by perfusion catheter, inject once every minute until ventricular fibrillation occurs, Measure the dose of ventricular fibrillation in the control group, compare with the drug group, do statistical treatment.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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