Cavia Model for Motor Neuron Disease (MND) Cavia (Guinea pig ) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by immunized with purified bovine spinal cord anterior horn motor neurons
  • Model Animal StrainsGuinea pig, male, healthy, body weight: 480~500g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period16w~18w
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  • Cavia Model for Motor Neuron Disease (MND) Packages (Simulation)
  • Cavia Model for Motor Neuron Disease (MND) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. Guinea pigs were immunized with fresh bovine spinal cord anterior horn homogenate, and 10 parts were injected subcutaneously at the back of the guinea pigs, each time for 4 weeks, for a total of 5 times.
2. The changes of light microscope and ultrastructure of spinal cord: anterior root and sciatic nerve were observed. Results the weight of guinea pigs decreased significantly after fourth immunization. Degeneration and loss of motor neurons in the anterior horn of the spinal cord.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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