Mouse Model for Jaundice Mus musculus (Mouse) Disease model

Icterus

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by ligation of common bile duct
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 6~8weeks, body weight: about 25g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period1~2w
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  • Mouse Model for Jaundice Packages (Simulation)
  • Mouse Model for Jaundice Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. Mice were treated with 1% sodium pentobarbital (30mg/mkg) after intraperitoneal anesthesia supine position, fixed on the operating table, skin preparation, iodine, alcohol disinfection of the surgical field, towel. Take the abdomen straight incision, about 1cm, according to the layer into the abdomen.
2. It is suggested that the duodenum, the common bile duct and the common bile duct should be double ligated and cut off the common bile duct to avoid the pancreatic tissue. Postoperative routine feeding.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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