Rabbit Model for Bullous Keratopathy (BK) Oryctolagus cuniculus (Rabbit) Disease model

Bullous keratitis

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by destroying corneal endothelial
  • Model Animal StrainsBig ears white rabbit, healthy, male and female, weight 1.5-2.5kg.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rabbit Model for Bullous Keratopathy (BK) Packages (Simulation)
  • Rabbit Model for Bullous Keratopathy (BK) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Weight 2.5 ~ 3.0 kg healthy adult New Zealand rabbits, by the ear by lml / kg body weight intravenous injection of 3% pentobarbital sodium Weight 2.5 ~ 3.0 kg healthy adult New Zealand rabbits, by the ear by lml / kg body weight intravenous injection of 3% pentobarbital sodium anesthesia, "Weight 2.5 ~ 3.0 kg healthy adult New Zealand rabbits, by ear margin according to LML/kg body weight dose of intravenous injection of 3% sodium pentobarbital anesthesia, made ball week 2 ml of 2% lidocaine anesthesia, with open eyelid open eyelid, microscope on side of gong of rabbit eyes make a 1.5 mm tunnel incision, where will the needle tip 5 bent into a 90 degree Angle, distance to the 10 mm to bend an obtuse Angle in the direction of the needle tip. Needle 5 ml syringe, with eye ophthalmic fluid balance by the tunnel into the anterior chamber, water injection to maintain anterior chamber and edges hook damage corneal endodermis. Microscopically visible endodermis falls off, off the scope of the cornea in 70% ~ 100% leather. Before washing, to rush out parts of endothelial fragments, and then water injection and withdrawal needles. Postoperative points with 0.5% of the nitrogen doxycycline eye drops, 4 times a day to prevent infection."

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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