Rat Model for Acute Pharyngitis (AP) Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by nebulization
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Acute Pharyngitis (AP) Packages (Simulation)
  • Rat Model for Acute Pharyngitis (AP) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Wistar SD rats 200g .Breeding level in a clean environment, every day, afternoon with throat spray on each with 15% ammonia spray animal pharyngeal 1 time, 3 days in a row, each use spray 3 press. Carefully observe animal appearance state every day, every day with medical head mirror and the pressure plate and observe one animal pharynx ministry, including mucosal morphology, color and so on. 4 days when the rat tail before death determination of blood smear of blood routine, and then after femoral artery bleeding to death, immediately remove the pharyngeal mucosa and the organization as a conventional biopsy specimens of transmission electron microscopy (sem) and production, make the microscopic pathological morphology and ultrastructure observation. Animals to be put to death the tail blood smear determination of blood routine.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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