Rat Model for Arrhythmia Rattus norvegicus (Rat) Disease model

Cardiac Arrhythmia

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by myocardial ischemia/reperfusion
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 250-450g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Periodn/a
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  • Rat Model for Arrhythmia Packages (Simulation)
  • Rat Model for Arrhythmia Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Use male rat with body weight of 250-450g, intraperitoneously anesthetized with 25% Uralan at a dose of 1.2 to 5g/kg. Fix the animal supine, piercing the needle electrode into the rat limbs subcutaneous electrocardiogram and ECG oscilloscope， Record a normal II lead ECG. Cut the skin at the middle of the neck, separate trachea for tracheal intubation, connect the artificial respirator, respiratory ratio is 1:2, respiratory rate is 60 times/min, tidal volume of 60ml/kg. Open chest between the 3rd and 4th rib, exposure to the heart and cut the pericardium, pierce the needle at the beginning of 2 mm of heart left anterior descending coronary artery and set a No. 1 silk, after 10min stability, then ligation of a 1cm long, 3 mm diameter plastic hose and arteries. Then start recording ECG every minute, continuously record 30 mins, and cut the thread along the plastic hose, make it reperfusion. Record an electrocardiogram every minute, continuous record 40min and observe the occurrence of arrhythmia. After recovery of coronary perfusion, the emergence of arrhythmia occur immediately, mainly for ventricular premature beats, ventricular tachycardia, ventricular fibrillation and atrioventricular block. The highest incidence occurred within 15 mins after reperfusion.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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