Rat Model for Behavioral Despair Depression (BDD) Rattus norvegicus (Rat) Disease model

Behavioral despair; Behavioral depression

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by swimming and tail suspension test
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Behavioral Despair Depression (BDD) Packages (Simulation)
  • Rat Model for Behavioral Despair Depression (BDD) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

(1)Male mice, weight 20 to 24 g. All mice were allowed to pre-swim the day before the experiment. The mice were placed in a 10 cm glass cylinder (20 cm in diameter, 14 cm in diameter) and 25 ° of the water temperature, make the mice swin for 6min, the animals were selected to stop swimming for at least 70 to 160 s for formal trials with a pass rate of about 60% .After 24 h, the animals were replaced into the above environment for 6 min swimming, The control group was stopped at 4 min after 6 min.The time of administration was also prolonged as needed, and the time of lh was measured after the last administration.The criteria of animal immobility were the rat microcircules, but kept Vertical posture, nostrils exposed to the surface(2)Male mice weighing 20 to 24 g. The tape is attached to a horizontal stick at 2 cm from the tip of the tail, so that the animals were in an upside-down state, the head is about 15 cm above the table. The mouse does not move within 6 min.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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