Rat Model for Hyperkalemia (HK) Rattus norvegicus (Rat) Disease model

Hyperkalaemia

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by injection of 10% potassium chloride (KCl) solution
  • Model Animal StrainsSD rats (SPF), male or female, healthy, weight 180~220g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period1 week
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  • Rat Model for Hyperkalemia (HK) Packages (Simulation)
  • Rat Model for Hyperkalemia (HK) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Choose the right or left side of the lower abdomen of rats injected with 10%KCL saline, the first choice in accordance with the dose of 0.4ml/100g injection, observe the ECG waveform, if the injection of potassium chloride after 15mins ECG waveform does not change and re infusion of potassium chloride 0.1ml, until the emergence of high potassium blood disease obvious abnormal ECG.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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