Rat Model for Menopausal Syndrome (MS) Rattus norvegicus (Rat) Disease model

Perimenopausal Syndrome; PS

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by injection of ethanol into bilateral ovaries
  • Model Animal StrainsSD rats (SPF), female, health, body weight 220g~240g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period4 weeks
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  • Rat Model for Menopausal Syndrome (MS) Packages (Simulation)
  • Rat Model for Menopausal Syndrome (MS) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. On aseptic conditions, 0.2 ml ethanol was injected into the bilateral ovaries of rats. The changes of serum estradiol and progesterone were observed every week, and the pathological changes of ovary were observed for 4 weeks.
2. Collect the blood for the orbit of the rats at 1st, 2nd, 3rd and 4th week. After the blood coagulation, the serum was collected by centrifugation, and stored at the -20 degree. ELISA method was used to determine the concentration of E2 and P in serum. The animals were sacrificed and the ovaries were removed and fixed in 10% formalin for routine histopathological examination.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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