Rat Model for Oral Ulcer (OU) Rattus norvegicus (Rat) Disease model

Mouth Ulcer

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Overview
Properties
  • Prototype SpeciesHuman
  • Sourceinduced by Charcoal burning
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Oral Ulcer (OU) Packages (Simulation)
  • Rat Model for Oral Ulcer (OU) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

SD rats 180 ~ 180g. Choosing a glass tube of 6cm of which the bottom diameter is 3mm, with a small cotton ball inside, making the bottom of the cotton ball and bottom of glass paralleled, and then dropping into the glass tube with 90% of the solution of carbonic acid until the small cotton ball soaked. Then lower end of the glass tube placed at the left side of the mouth of the buccal mucosa, burning for 30s, see the mucosa appeared in the area of about white damage of 3mm. After 24 hours, the rat left cheek test area formed a diameter of 30 ~ 35mm round or oval ulcer, about 0.5mm deep and the surface covered with off-white pseudomembrane. Observing the flushing, swelling, and pain of oral mucosa for several days after dosed separetly, measuring the temperature of mouth and ulcer surface diameter with a vernier caliper and then analyze statistically.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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