Rat Model for Osteoporosis (OP) Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by hydrocortisone
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Osteoporosis (OP) Packages (Simulation)
  • Rat Model for Osteoporosis (OP) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Orally drench rats 3-month-old rats with hydrocortisone injection at the dosage of 3.6mg/kg for 6 times every week and then for twice every week after 30 d. The administration lasts for 60 d in total. 10 d and 2 d before being killed, rats are subcutaneously injected with tetracycline hydrochloride at the dosage of 25 mg/kg and Calein solution at the dosage of mg/kg respectively so that fluorescent double labels can be formed on their bone surfaces; in this way, we can observe the dynamic change in bone formation between 2 injections.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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