Rat Model for Renal Fibrosis (RF) Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • Sourceinduced by Unilateral renal vein ligation
  • Model Animal StrainsWistar Rats(SPF), healthy, male and female, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Renal Fibrosis (RF) Packages (Simulation)
  • Rat Model for Renal Fibrosis (RF) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Weight 200 ~ 250 g in rats, the abdominal weight is 0.1 ml/kg dose injection of 8.5% chloral hydrate anesthesia, animal fixed lines lie on back, regular disinfection abdominal skin and take hairs; Along the belly line incision, cut in the skin and muscle, free of left kidney, the separation of the left renal vein, with 4-0 surgical suture ligation, then normal skin and muscle, close the abdominal cavity.Postoperative conventional single cage, free drinking and eating.After 5, 10, 15, 20 and 25 days, anesthesia animal right femoral artery bleeding to death, separation of serum content of serum creatinine (SCr);To be put to death before the 1 d in fast under the condition of water, collect the 24h urine test gauges in rats.Take the left kidney tissue specimens after 10% formaldehyde fixed, as conventional biopsy were observed under microscope.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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