Rat Model for Withdrawal Syndrome (WS) Rattus norvegicus (Rat) Disease model

Discontinuation syndrome

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by alcohol
  • Model Animal StrainsSD rats (SPF class), Male, 6~8W, 200~250g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period4~8 weeks
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  • Rat Model for Withdrawal Syndrome (WS) Packages (Simulation)
  • Rat Model for Withdrawal Syndrome (WS) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

The rats were fed with 6% alcohol solution 28d, after withdrawal of alcohol observed the withdrawal syndrome .

Model evaluation

Alcohol withdrawal after 24h, the rats were sacrificed, the brain, the content changes of cerebral cortex in p-CREB and BDNF were detected by QPCR method, the results show that the alcohol withdrawal 24h in the cerebral cortex p-CREB, BDNF decreased significantly.

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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