Myosin Light Chain 1, Alkali, Fast Skeletal (MYL1)

MLC1; MLC1F; MLC3F; Myosin light chain 1/3, skeletal muscle isoform; Myosin light chain A1/A2

Myosin Light Chain 1, Alkali, Fast Skeletal (MYL1)

In vertebrate striated muscle, myosin is composed of 2 heavy chains of about 200,000 daltons each and 4 light chains of about 20,000 daltons each. The light chains are of 2 distinct types: the phosphorylatable, regulatory, or MLC2 type, and the nonphosphorylatable, alkali, or MLC1 and MLC3 types (MYL1 according to the HGM symbols). The previously uncharacterized zebrafish alkali-like myosin light chain gene (myl1) was found to be expressed exclusively in cells in the fast-twitch pathway initiated at an early stage of fast fibre differentiation. Myl1 was expressed earlier, and in a more fibre type restricted manner, than any of the previously described and frequently used fast myosin light and heavy chain and troponin muscle markers mylz2, mylz3, tnni2, tnnt3a, fMyHC1.3.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)