Interleukin 12B (IL12B)

p40; IL12-B; CLMF2; NKSF2; Natural Killer Cell Stimulatory Factor 2; Cytotoxic Lymphocyte Maturation Factor 2; Interleukin 23, P40 Subunit
Interleukin 12B (IL12B)
IL12B, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
Organism species: Cavia (Guinea pig )
Organism species: Canis familiaris; Canine (Dog)
Organism species: Sus scrofa; Porcine (Pig)
Organism species: Bos taurus; Bovine (Cattle)
Organism species: Capra hircus; Caprine (Goat)
Organism species: Equus caballus; Equine (Horse)
Organism species: Chicken (Gallus)
Organism species: Rainbow trout
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