In mammalian cells, vinculin
is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Its sequence is 20-30% homologous to α-catenin, which serves a similar function.
Vinculin is a 117 kDa cytoskeletal protein with 1066 amino acids. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. Vinculin consists of a globular head domain that contains binding sites for talin and α-actinin as well as a tyrosine phosphorylation site, while the tail region contains binding sites for F-actin, paxillin and lipids.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
||Recombinant Vinculin (VCL)
||Polyclonal Antibody to Vinculin (VCL)
||Monoclonal Antibody to Vinculin (VCL)
||ELISA Kit for Vinculin (VCL)
||CLIA Kit for Vinculin (VCL)