Polyclonal Antibody to Quinolinic Acid (QA) Pan-species (General) Polyclonal antibody

QUIN; Pyridine-2,3-Dicarboxylic Acid

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Overview
Properties
  • SourcePolyclonal antibody preparation, Host Rabbit
  • Ig Type IgG, Potency n/a
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen CPK552Ge21-OVA Conjugated Quinolinic Acid (QA)
  • Buffer Formulation0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
  • TraitsLiquid, Concentration 0.5mg/ml
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  • Polyclonal Antibody to Quinolinic Acid (QA) Packages (Simulation)
  • Polyclonal Antibody to Quinolinic Acid (QA) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Specifity

The antibody is a rabbit polyclonal antibody raised against QA. It has been selected for its ability to recognize QA in ELISA and CLIA.

Usage

Enzyme-Linked Immune Sorbent Assay:384µg/ml
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

Storage

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Stability

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Giveaways

Citations

  • M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.pubmed:27870896
  • Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2, 3-dioxygenase and neurodegenerationpubmed:28599322
  • Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of RatsPubmed:29725904
  • Exercise training impacts skeletal muscle gene expression related to the kynurenine pathwayPubmed: 30649918
  • Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat modelPubmed: 31257634
  • Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patientsPubmed: 31727978
  • Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progressionPubmed: 32268268

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