Dual Guardian: Decoding the Key Role of Toll-like Receptors in Immunity and Disease1. Introduction ofthe Toll-like receptor familyToll-like receptors (TLRs) are a group of pattern recognition receptors that play a significant role in the development and maintenance of the immune system. These receptors can recognize foreign pathogen-associated molecular patterns (PAMPs) as well as endogenous by-products of cell damage, namely damage-associated molecular patterns (DAMPs). Signal transduction through TLR leads to the production of pro-inflammatory cytokines and other inflammatory response mediators. Therefore, TLR and its signaling pathway effectors are crucial for the functions of both ......

Decoding the "Invisible Army" of the Human Body: How Does Your Immune System Safeguard Your Health?The immune system is a sophisticated and complex defense network in the human body, composed of cells, tissues and organs. Its core mission is to identify and eliminate "non-self" substances, such as pathogens (bacteria, viruses, fungi, parasites), foreign substances (such as transplanted organs, pollen, dust), and abnormal cells within the body (such as cancer cells), while avoiding attacking its own healthy tissues, thereby maintaining the health and stability of the body. The immune system is generally divided into two major parts: "innate immunity" and &q......

Diabetes is a serious health problem worldwide. It is caused by chronic high glucose levels in the blood as a result of the incapability of β cells in the pancreas to produce adequate insulin or ineffective insulin utilization by cells in the body. There are generally 3 types of diabetes: Type I, II and gestational diabetes but more emphasis is placed on the first 2 types of diabetes. As a chronic condition, diabetes tends to increase the risk of several other diseases caused by macrovascular and microvascular damage, and it has negative impacts on several organs, such as the brain, kidney, heart, and eyes. In addition, diabetic patients are more susceptible to infection.Insulin is a p......

The MAPK/ERK signaling pathway: A core hub from basic biology to human diseases1. Introduction of the MAPK PathwayThe mitogen-activated protein kinase (MAPK) cascade is a key signaling pathway regulating various cellular processes, including proliferation, differentiation, apoptosis and stress response. The MAPK pathway functions through signal cascades, transmitting extracellular signals to intracellular targets, enabling cells to respond to various specific extracellular stimuli. The MAPK pathway includes three major kinases, namely MAPK kinase-kinase (MAP3K), MAPK kinase (MAPKK), and MAPK, which activate and phosphorylate downstream proteins. Current research has identified four maj......

From Immune Storm to Nerve Damage: Decoding the "Source of Multiple Diseases" Role of JAK KinaseJAKs are a class of non receptor tyrosine kinases, including four members: JAK1, JAK2, JAK3, and TYK2. They participate in regulating various biological processes such as hematopoiesis, immune response, inflammation, and cell survival through interactions with cytokine receptors. In recent years, the role of JAKs in the occurrence and development of various diseases has gradually been revealed. In addition to malignant tumors, abnormal activation of the JAK signaling pathway is a key driving factor in inflammatory autoimmune diseases (such as rheumatoid arthritis, psoriasis), aller......

JAK Family Decoding: Key Hubs and Potential Targets in Tumors1. Introduction of the JAK FamilyJanus kinase (JAK) is an intracellular non-receptor tyrosine kinase that transduces cytokine-mediated signals through the JAK-signal transducer and activator of Transcription (JAK-STAT) pathway. The name "Janus" is derived from the Roman god Janus, who has two faces, because JAK has two similar phosphate transfer domains, one of which shows kinase enzyme activity, while the other motif negatively regulates the kinase activity of the former in the feedback loop.1.1 Structure of the JAK FamilyThe JAK family consists of four members: JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). And th......