Mouse Knockout Leptin (LEP) Mus musculus (Mouse) Knockout

OB; OBS; Obesity Homolog; Obesity Factor; Obese Protein

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  • SourceComplete Knockout
  • HostMus musculus (Mouse)
  • StrainB6;129
  • Technical MethodsCRISPR-Pro
  • Culture ConditionSPF (Breeding Licensed)
  • Breeding GenerationF2p
  • TraitsFrozen Embryo
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  • Mouse Knockout Leptin (LEP) Packages (Simulation)
  • Mouse Knockout Leptin (LEP) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered



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  • Effect of Argyreia speciosa root extract on cafeteria diet-induced obesity in ratsIjp: source
  • Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbitPubMed: 22010203
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  • Ovarian, metabolic and endocrine indexes in dairy cows with different body condition scoresIfzz: Source
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  • Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar RatsPubmed:Pmc4363645
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  • Dietary Niacin Supplementation Suppressed Hepatic Lipid Accumulation in Rabbitspubmed:27004817
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  • Estimation of the intramuscular fat content of m. longissimus thoracis in crossbred beef cattle based on live animal measurements.pubmed:27940421
  • Correlation of Leptin, Insulin and Glucose During Late Gestation and Early Lactation in Murrah Buffaloes7086
  • Effects Of Maca (Lepıdıum Meyenıı Walp) Powder On Serum Indıces And Metabolıc Responses In Racehorses57cf073008ae83b37462323a.pdf
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  • Metabolomics for the effect of biotin and nicotinamide on transition dairy cowsPubmed:29758980
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  • Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae)Pubmed:29626477
  • Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis—Normalization After Liver Transplantation and Implications …Pubmed:29912265
  • The Effect of Aerobic Training on Tumor Growth, Adiponectin, Leptin and Ghrelin in Mice with Breast Cancerircmj-20-03-13305.pdf
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  • Epigallocatechin-3-gallate suppresses differentiation of adipocytes via regulating the phosphorylation of FOXO1 mediated by PI3K-AKT signaling in 3T3-L1 …Pubmed:29484120
  • Combinational Effect of Pine Needle Polysaccharide and Kudzu Flavonoids on Cell Differentiation and Fat Metabolism in 3T3-L1 CellsDoi: 10.3136/fstr.24.903
  • Effects of Metformin Combined with Lactoferrin on Lipid Accumulation and Metabolism in Mice Fed with High-Fat DietPubmed: 30400147
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  • Effect of fermented food consumption on biochemical parameters and adipokines levelsDoi: 0.23751/pn.v20i4.7374
  • Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose dietPubmed: 30530230
  • Effects of Diet-Induced Early-Stage Obesity on a Low-Testosterone Gottingen Minipig
  • Obesity Aggravates Acute Pancreatitis via Damaging Intestinal Mucosal Barrier and Changing Microbiota Composition in RatsPubmed: 30635594
  • Cardiotrophin-1 and leptin as cardiovascular risk markers in male patients with obstructive sleep apnea syndromePubmed: 30775602
  • Impact of exposure to diesel exhaust during pregnancy on mammary gland development and milk composition in the rabbitPubmed: 30763367
  • Effect of High Intensity Interval Training (HIIT) on visceral and subcutaneous levels of leptin and plasma insulin and glucose in male Wistar rats
  • The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic …Pubmed: 30870482
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  • 冷暴露对高脂饮食小鼠脂肪棕色化的影响
  • Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise trainingPubmed: 31290696
  • A dietary polysaccharide from Eucheuma cottonii downregulates proinflammatory cytokines and ameliorates osteoarthritis-associated cartilage degradation in obese …
  • High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights …
  • Puberty is a critical window for the impact of diet on mammary gland development in the rabbitPubmed: 31348557
  • The Effect of Different Types of Bariatric Surgery on Metabolic and Hormonal Parameters in Rats with a Decompensated Form of Type II Diabetes MellitusPubmed: 31228372
  • Paternal chronic folate supplementation induced the transgenerational inheritance of acquired developmental and metabolic changes in chickensPubmed: 31506054
  • Collaborative Effects of Chlorogenic Acid and Caffeine on Lipid Metabolism via AMPKα-LXRα/SREBP-1c Pathway in High-Fat Diet-Induced Obese MicePubmed: 31670366
  • Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig modelPubmed: 31756448
  • Serum Asprosin Concentrations Are Increased and Associated with Insulin Resistance in Children with ObesityPubmed: 31775140
  • Upregulation of MC4R and PPAR-α expression mediates the anti-obesity activity of Moringa oleifera Lam. in high-fat diet-induced obesity in ratsPubmed: 31911179
  • Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase InhibitorsPubmed: 32196343
  • Salivary Leptin and Chemerin; a novel way of gestational diabetes screeningPubmed: 32274942
  • RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose HomeostasisPubmed: 32328034
  • Copeptin and Nesfatin-1 Are Interrelated Biomarkers with Roles in the Pathogenesis of Insulin Resistance in Chinese Children with ObesityPubmed: 33027789
  • The effect of metformin treatment on the basal and gonadotropin‐stimulated steroidogenesis in male rats with type 2 diabetes mellitusPubmed: 32951228
  • Adipokines expression profiles in both plasma and peri renal adipose tissue in Large White and Meishan sows: a possible involvement in the fattening and …Pubmed: 32827511
  • C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins—possible link to metabolic programming?Pubmed: 32778645
  • Ameliorative Effect of Ananas comosus on Cobalt Chloride-Induced Hypoxia in Caco2 cells via HIF-1α, GLUT 1, VEGF, ANG and FGFPubmed: 32654099
  • Serum leptin level is associated with phase angle in CKD5 patients not undergoing dialysisPubmed: 30089154
  • Blastomere removal affects homeostatic control leading to obesity in male micePubmed: 33112292
  • The Effect of Diet-Induced and Melanocortin Obesity on Expression of Tryptophan Hydroxylase 2 in the Dorsal Raphe Nucleus and Ventral Tegmental Area in Mice
  • Peripheral concentrations of metabolic and inflammatory indicators during transition period and their relationship with postpartum clinical endometritis in dairy …
  • Altered hematopoietic system and self-tolerance in Bardet-Biedl Syndrome
  • Serum leptin and body mass index in a sample of Egyptian multiple sclerosis patients

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