17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12)
KAR; SDR12C1; Estradiol 17-beta-dehydrogenase 12; 3-Ketoacyl-CoA Reductase; Short Chain Dehydrogenase/Reductase Family 12C,Member 1
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HSD17B12 uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.The human HSD17B12 gene encodes a protein of 312 amino acids containing a dilysine endoplasmic reticulum (ER)-retention motif at the C terminus and 4 predicted transmembrane domains. Mouse and human HSD17B12 share 82% amino acid identity. Northern blot analysis showed expression of a 2.9-kb HSD17B12 transcript in all human tissues tested, with highest levels seen in liver, muscle, and kidney. Analysis of liver HSD17B12 mRNA in transgenic mice with altered levels of sterol regulatory element-binding proteins (SREBPs) showed no change in HSD17B12 expression compared to wildtype mice, suggesting that HSD17B12 is not regulated by SREBPs.
Organism species: Homo sapiens (Human)
- Recombinant protein RPF182Hu01 Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Polyclonal antibody PAF182Hu01 Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Customized Service n/a CLIA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPF182Mu01 Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Polyclonal antibody PAF182Mu01 Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Customized Service n/a CLIA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPF182Ra01 Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Polyclonal antibody PAF182Ra01 Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Labelled antibody LAF182Ra81 FITC-Linked Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Labelled antibody LAF182Ra71 Biotin-Linked Polyclonal Antibody to 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) In Stock
- Customized Service n/a CLIA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) ELISA Kit Customized Service Offer