3-Beta-Hydroxysteroid Dehydrogenase Type 5 (HSD3b5)
Progesterone reductase; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
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One noted change was the dose-dependent suppression of the mouse hormone metabolizing 3β-hydroxysteroid dehydrogenase V (HSD3b5), which is specifically expressed in the male mouse liver. Northern analysis showed that HSD3b5 mRNA levels decreased dramatically upon one-day exposure to 2.0% dietary DEHP, and were nearly undetectable by one week of treatment. Food restriction also significantly suppressed HSD3b5 expression; however, in this case the suppression was delayed and to a lesser extent. Another mouse 3β-hydroxysteroid dehydrogenase, HSD3b4, predominantly expressed in kidneys, was also regulated by DEHP and food restriction. The sex-specific gene, HSD3b5, was affected more by DEHP and food restriction than the tissue-specific gene, HSD3b4.
Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a CLIA Kit for 3-Beta-Hydroxysteroid Dehydrogenase Type 5 (HSD3b5) CLIA Kit Customized Service Offer
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