3-Hydroxybutyrate Dehydrogenase 2 (BDH2)
DHRS6; UCPA-OR; SDR15C1; Dehydrogenase/Reductase Member 6; Short Chain Dehydrogenase/Reductase Family 15C, Member 1; R-beta-hydroxybutyrate dehydrogenase
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DHRS6 is a previously uncharacterized member of the short chain dehydrogenases/reductase family. Substrate screening reveals sole NAD(+)-dependent conversion of (R)-hydroxybutyrate to acetoacetate with K(m) values of about 10 mm, consistent with plasma levels of circulating ketone bodies in situations of starvation or ketoacidosis. DHRS6 was determined at a resolution of 1.8 A in complex with NAD(H) and reveals a tetrameric organization with a short chain dehydrogenases/reductase-typical folding pattern. A highly conserved triad of Arg residues was found to bind a sulfate molecule at the active site. Docking analysis of R-beta-hydroxybutyrate into the active site reveals an experimentally consistent model of substrate carboxylate binding and catalytically competent orientation.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) ELISA Kit Customized Service Offer