5-Hydroxytryptamine Receptor 5A (HTR5A)

HTR5A encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G proteins, negatively influencing cAMP levels via G_i and G_o. This protein has been shown to function in part through the regulation of intracellular Ca²⁺ mobilization. Rodents have been shown to possess two functional 5-HT₅ receptor subtypes, 5-HT_5A and 5-HT_5B, however while humans possess a gene coding for the 5-HT_5B subtype, its coding sequence is interrupted by stop codons making the gene non-functional, and so only the 5-HT_5A subtype is expressed in human brain.however while humans possess a gene coding for the 5-HT_5B subtype, its coding sequence is interrupted by stop codons making the gene non-functional, and so only the 5-HT_5A subtype is expressed in human brain.