5-Hydroxytryptamine Receptor 1A (HTR1A)

The receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxtryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to G_i/G_o and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor. The 5-HT_1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT_1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucelus in high densities, while low amounts also exist in the basal ganglia and thalamus. The 5-HT_1A receptors in the raphe nucleus are largely somatodendritic autoreceptors. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan.