Autophagy Related Protein 16 Like Protein 1 (ATG16L1)

Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.

The deduced 607-amino acid protein has a calculated molecular mass of 68.2 kD and shares 90% identity with one of the mouse Atg16l1 isoforms. All 4 ATG16L1 isoforms have an N-terminal coiled-coil domain, and the 3 longest isoforms have 7 C-terminal WD repeats. The shortest isoform has only 3 C-terminal WD repeats.