ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a)

ATP12a belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.

The deduced 1,039-amino acid protein has a calculated molecular mass of 114.5 kD. ATP1AL1 has all the features of catalytic subunits of P-type ion-transporting ATPases, including a catalytic phosphorylation site (asp391), components of the ATP-binding site (asp732 and asp736), and 10 potential transmembrane domains spaced throughout the molecule. Highest ATP1AL1 expression was detected in skin.