Actinin Alpha 4 (ACTN4)
FSGS; FSGS1; F-actin cross-linking protein; Non-muscle alpha-actinin 4
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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Alpha-actinin-4 is a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Organism species: Homo sapiens (Human)
- Recombinant protein RPC223Hu01 Recombinant Actinin Alpha 4 (ACTN4) In Stock
- Recombinant protein RPC223Hu02 Recombinant Actinin Alpha 4 (ACTN4) In Stock
- Polyclonal antibody PAC223Hu01 Polyclonal Antibody to Actinin Alpha 4 (ACTN4) In Stock
- Monoclonal antibody MAC223Hu21 Monoclonal Antibody to Actinin Alpha 4 (ACTN4) In Stock
- Polyclonal antibody PAC223Hu02 Polyclonal Antibody to Actinin Alpha 4 (ACTN4) In Stock
- Sandwich ELISA SEC223Hu ELISA Kit for Actinin Alpha 4 (ACTN4) In Stock
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Actinin Alpha 4 (ACTN4) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Actinin Alpha 4 (ACTN4) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Actinin Alpha 4 (ACTN4) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Actinin Alpha 4 (ACTN4) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Actinin Alpha 4 (ACTN4) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Actinin Alpha 4 (ACTN4) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Actinin Alpha 4 (ACTN4) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Actinin Alpha 4 (ACTN4) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Actinin Alpha 4 (ACTN4) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Actinin Alpha 4 (ACTN4) ELISA Kit Customized Service Offer